The Department of Pediatrics is pleased to announce the appointment of Jamie Aye, M.D. associate professor in the Division of Pediatric Hematology/Oncology and Blood & Marrow Transplantation, as director of the Developmental Therapeutics (DVL) Program within the Division of Pediatric Hematology, Oncology, and Blood & Marrow Transplantation (BMT) at the University of Alabama at Birmingham (UAB).

Dr. Aye has served as associate director of the program since 2023, working toward the mission of discovering, developing, and delivering more effective and less toxic therapies for children with cancer and blood disorders through translational research and early-phase clinical trials. In her new role, she will strengthen collaborations between basic and translational researchers across departments at UAB and beyond, advancing investigator-initiated clinical trials in pediatric hematology-oncology. These collaborative efforts will support preclinical development and validation of novel biomarkers, imaging techniques, and therapeutic agents, including targeted therapies and immunotherapies.

As director, Dr. Aye will also engage with pharmaceutical industry partners, national clinical trial consortiums, and the Pediatric Clinical Trials Office at Children’s of Alabama to expand access to early-phase clinical trials for our patients. She will continue to lead the program’s annual retreat to highlight progress and foster continued innovation.

Dr. Aye earned her undergraduate degree from Wake Forest University and her medical degree from Mercer University School of Medicine. She completed her pediatric residency at the University of South Carolina School of Medicine and her pediatric hematology-oncology fellowship at UAB. She joined the faculty at UAB and Children’s of Alabama in 2018 and currently serves as associate professor of Pediatrics and associate scientist in the Experimental Therapeutics Program of the O’Neal Comprehensive Cancer Center at UAB. Her clinical and research interests focus on solid tumors, particularly sarcomas. Dr. Aye is an active member of the Soft Tissue Sarcoma Committee of the Children’s Oncology Group and serves on both the Protocol Committee and the Rhabdomyosarcoma Taskforce within the National Pediatric Cancer Foundation’s Sunshine Project, a consortium dedicated to early-phase clinical trials. She has also served as medical director of Inpatient Services for the pediatric hematology-oncology division since 2020.